COVID-19 Research: A new study by Russian medical researchers suggests that deficiency of endogenous glutathione could also be another influencing factor of the degree of susceptibility by individuals towards the SARS-CoV-coronavirus that causes the deadly COVID-19 disease.
The research lead by Dr Alexey V Polonikov , a Professor from Department of Biology and Medical Genetics of Kursk State Medical University, Russia shows that lack or deficiency of endogenous glutathione especially in the older individuals could also be one of the contributing factors leading to the progression of the disease from mild infection to severe conditions. https://www.researchgate.net/publication/340917045_Endogenous_deficiency_of_glutathione_as_the_most_likely_cause_
Deficiency of glutathione has already been demonstrated through past studies to be associated with growing number of chronic diseases including diabetes. As a person ages, glutathione levels typically falls and men also tend to have lower glutathione levels than women as they age.
Glutathione is also anti-oxidant that has also demonstrated antiviral properties in past studies. Its helps prevent oxidative stress and also inflammation and also helps boost the functions of immune cells. …
… Glutathione (GSH) is an endogenous antioxidant and an important cellular defense agent against oxidative damage. GSH reacts with the free radicals in the cell and reduces the entry of hydrogen peroxides . GSH also prevents the oxidization of sulfhydryl groups in the protein structure. GSH levels in tissues are often used as a marker for measuring radical damage. It acts as a substrate for antioxidant enzymes that causes resistance to radical-induced damage, behaving like a radical scavenger. GSH is especially important for the activity of glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). In the oxidative stress process, levels of GSH decrease, while glutathione disulfide increases. In this case, accumulation of hydrogen peroxide (H2O2) is scavenged by the effects of reductase and glutathione peroxidase (GSH-Px). GSH-Px is also an important enzyme, which prevents damage to phagocytic cells caused by free radicals. A decrease in GSH-Px activity leads to the accumulation of hydrogen peroxide and to cell damage. GSH-Px also prevents the initiation of lipid peroxidation .
EMF emitted by cellular phones is known to be related to a decreased level of GSH in brain tissue and blood . However, a decreased level of blood GSH may possibly be explained by an elevated oxidation rate and use of GSH during the elimination of lipid and other peroxides . Awad and Hassan investigated the brains of rats exposed to 900-MHz EMF from mobile phones for 1 h/day for one week. They observed an increase in lipid peroxidation after exposure to mobile phones .
Aydın and Akar studied the effect of 900-MHz EMF for 2 h/day for 45 days on lymphoid organs in immature and mature rats. They reported that CAT and GPx activities decreased significantly compared to a control group. Similarly, an increase in lipid peroxidation and a concomitant demolition in GSH levels were seen in all lymphoid organs after EMF exposure, suggesting that increased levels of lipid peroxidation may have been a consequence of depleted GSH stores . Luo et al. investigated that the whether the protective effects of LSPCs performed by oral gavage on oxidative stress injury induced by ELF-EMF exposure. According the results, GST activity was significantly decreased in the ELF-EMF group when compared with the control group. They found that LSPCs could effectively prohibit oxidative stress damage induced by ELF-EMF exposure, it may be related to the ability to remove free radicals and induce antioxidant enzyme activity . Singh et al. investigated the biochemical mechanism of the interaction of 900-MHz mobile phone EMF with root formation in mung bean hypocotyls. The obtained results showed up regulation of the activities of antioxidant enzymes such as CAT and GR, which protect against oxidative damage induced by EMF . Sepehrimanesh et al. studied that effect of 900-MHz electromagnetic field (EMF) exposure on rat serum and testes antioxidant enzyme levels. They observed that after 30 days exposure both SOD and GPx activities decreased in the long-time EMF exposure group . In the other study RF-EMF exposure caused increase antioxidant stress response via increase of CAT and GR activity it lead to the generation of lipid and protein oxidative damage . …