Supplementing with Melatonin & Ascorbic Acid for COVID-19 – A Simple Guide


… Supplementing with Melatonin & Ascorbic Acid for COVID-19 – A Simple Guide

Please understand the following is NOT MEDICAL ADVICE.  Please consult your trusted physician regarding COVID-19 treatment, especially if you have comorbidities like CVD, hypertension, diabetes, respiratory diseases and cancer.

Maintenance Dosages During COVID-19 Pandemic


Exogenous intake during COVID-19 is recommended only because normal endogenous production for adults may not be adequate for protection against COVID-19.  Children under nine are protected from COVID-19 because they have up to TEN TIMES the ‘normal’ amount of adults. Our high tech environment, light pollution at night have already vastly diminished the normally low level of melatonin in adults. Supplementing with a minimum physiological dose during COVID-19 pandemic can provide additional protection against infections.

If you are an adult without major health challenges, you should take no more than the physiological dosage recommended below.

The following dosage is a range. The higher end of the range applies to people who are older or have slightly weaker health.  So if you are a young healthy adult, you may require no more than the lowest physiological dose of  0.2 mg.

Physiological dose:  0.2 milligram to 0.5 milligram per day

Please take melatonin at night, about 1 to 2 hours before sleep and 2 to 3 hours AFTER your last meal.  You should ideally finish eating before it is dark.

It is also extremely helpful if you can lower your ambient lighting at night, as the lowest amount of light will disrupt melatonin production.  Melatonin is produced in all cells, including mitochondria, not just in pineal glands [100].

Ascorbic Acid 

Again, your age matters because of the level of endogenous melatonin.  If you are older or more susceptible to COVID-19 for various reasons, your maintenance dose should be one gram per hour, to total 10-18 grams per day, depending on your tolerance level.  You will experience loose stools, or what is known as hitting Bowel Tolerance if you have saturated your system with ascorbic acid.

Dosage During COVID-19 Infection

If you suspect infection, notify authorities in charge and your physician immediately.  If you are self-quarantined at home, the following dosage applies.


Melatonin COVID-19 Infection Dosage:  5 milligrams to 50 milligrams

The lower range is for people with mild or no symptoms.  The higher range is for older people or those with more severe symptoms.

IF you are taking ACE inhibitors, have cardiac conditions, hypertension, you need to consult your physician before taking high doses of melatonin.  Melatonin may lower blood pressure and cause hypotension at higher dosages.  

The Infection dose should ideally be divided into DAYTIME and NIGHTTIME doses.

DAYTIME – 40% of total daily dose, divided into small equal portions to be taken every TWO HOURS.

NIGHTTIME –  60% of total daily dose, divided into two portions taken 2-3 hours after dinner.  The final dose at night should be completed by 10 pm (latest).

IF you are diabetic, or have insulin resistance, DO NOT TAKE MELATONIN before 3 pm.  Melatonin is able to suppress insulin.

Please remember that oral dosage higher than physiological concentration is applicable during infections only.  Supplementation of high dose melatonin MUST BE SUPPORTED by ascorbic acid. You may not experience full benefits of melatonin in the absence of ascorbic acid. 

Ascorbic Acid 

Ascorbic Acid COVID-19 Infection Dosage:  1 gram every 15 to 30 minutes, depending on severity of symptoms. Increase to 2 grams every 15 to 30 minutes if symptoms are not reversed within 12-24 hours.  

IF you are infected, you will essentially have an ‘unlimited’ tolerance for ascorbic acid.  Your tolerance may increase above 100 grams or more. That is normal.

During infection, rest, drink plenty of purified water.  You may lose your appetite. Do not force yourself to eat if you are not hungry.  Calorie restriction initiates mitophagy and autophagy, which will facilitate healing [101].

The journey ahead for everyone in every corner of the world will prove to be challenging.  During this time of darkness, we must keep absolute faith that Nature has protected our ancestors for millions of years, even under extinction conditions.  Nature will NOT fail us with COVID-19, as long as we stay true to her intentions. Blessings to all….

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