In 1972 Monsanto began marketing Round-up® as an herbicide, with three claims which later proved to be misleading at best, untrue at worst (1). The first claim is that the mode of action was to block the Shikimic Acid pathway – a biochemical series of steps that throughout biology produces three diet-essential amino acids (AA), needed for all protein synthesis. These are the same three, out of the twenty coded for by all DNA-RNA synthesis, which contain phenolic rings: Phenylalanine (F), Tyrosine (Y) and Tryptophan (W). The second claim continued: since human biochemistry does not contain this pathway, the herbicide is harmless. This immediately raised the question: Where then do we get the three AA for all our own synthesis, and the answer is two-fold: from our diet and from our gut microbiome. Once the use of Round-up became common, crops are grown with residues, so that our diet in fact became very short of the three, F,Y and W. Worse, the residues in our food have a disastrous effect on our gut microbiome, from which we now depend for F, Y and W. Blocking the Shikimate path in your gut causes the precursors of the process to build up, and especially the toxin m-cresol, which first KILLS OFF the helpful bacteria then pathogenic bacteria take over. The Clostridium bacteria quickly over grow and produce more cresol, which they tolerate. This hostile takeover is accompanied by another disaster, far more permanent in its effect on your health: the tight junctions in the gut lining, which we depend on to seal the fluids in the gut from the blood itself, become leaky, and Crohn’s disease then permits huge molecules, like Aluminum and antigenic large chain food proteins to join the blood stream. But the drama of chronic ill health is just getting started. Most of your immune system is not only located along the gut wall from end to end, but it is linked to your private colony of microbes. This in turn, is linked to your brain, so that moods are largely dictated by the biome on a minute-by-minute basis.
As if these extensive injuries were not sufficiently distressing, glyphosate deprives the liver of its most necessary detoxification capability. It is a series called the Cytochrome P450 inducible enzymes, capable of reducing the impact of the cresol and other bacterial endotoxins (2) (3) (4).
The combination of triple disasters: unhandled toxins, loss of mood guidance and blood suddenly filled with foreign material, causes what amounts to a four-alarm fire in the immune system. Called a cytokine storm, the immune system is activated by the cytokines, and begins the week-long process of developing antibodies against food antigens, as well as hastening immune cells called to the brain, in responding to the impaired mood state. Recovery from the many problems will take from weeks to years….