Forcibly Amputated Male Foreskins Profit Cosmetic, Biotech Industries

This is from two of the references in my circumcision paper linked above.  No one reads footnotes so I thought I’d call attention to this specific problem.  They used to call this “human vivisection” but these days it’s just business as usual.  And if you think this is the worst depravity that you’ll find in the paper, check out the links in reference 102.  Or hell, check out reference 9, that’s bad enough.  This is emperor’s new clothes stuff.  All it takes is mass awareness and the resultant mass outrage will put a stop to it.  No one is listening to the babies because they don’t speak gramatically correct english while they’re being sexually tortured.  Will you help speak for them?

Medical Journal Articles from 1969 to 1998 Documenting
The Use of Human Foreskins in Medical, Pharmaceutical, and Other Commercial Enterprises

A universal MEDLINE search on 25 April 1998 using the key words “Foreskin Fibroblasts” (the term used for harvested foreskins after they are processed for sale) yielded 471 articles. The articles with “human foreskin fibroblasts” in their titles are listed below.
PGE1 but not PGI2 desensitizes the PGI2 receptor-adenylate cyclase complex in human foreskin fibroblasts. Gorman-RR; Hopkins-NK. Adv-Prostaglandin-Thromboxane-Res. 1980; 8: 1717-21.

Agonist-specific desensitization of PGI2-stimulated cyclic AMP accumulation by PGE1 in human foreskin fibroblasts. Gorman-RR; Hopkins-NK. Prostaglandins. 1980 Jan; 19(1): 2-16.

Inhibition of androgen binding in human foreskin fibroblasts by antiandrogens. Brown-TR; Rothwell-SW; Sultan-C; Migeon-CJ. Steroids. 1981 Jun; 37(6): 635-48.

Growth of human foreskin fibroblasts in a serum-free, defined medium without platelet-derived growth factor. Weinstein-R; Hoover-GA; Majure-J; van-der-Spek-J; Stemerman-MB; Maciag-T. J-Cell-Physiol. 1982 Jan; 110(1): 23-8.

Characterization of steroid binding specificity of the androgen receptor in human foreskin fibroblasts. Cunningham-GR; Lobl-TJ; Cockrell-C; Shao-TC; Tindall-DJ. Steroids. 1983 May; 41(5): 617-26.

Inhibition of androgen metabolism and binding by a liposterolic extract of “Serenoa repens B” in human foreskin fibroblasts. Sultan-C; Terraza-A; Devillier-C; Carilla-E; Briley-M; Loire-C; Descomps-B. J-Steroid-Biochem. 1984 Jan; 20(1): 515-9.

Preferential binding of benzo[a]pyrene diol epoxide to the linker DNA of human foreskin fibroblasts in S phase in the presence of benzamide. Kurian-P; Jeffrey-AM; Milo-GE. Proc-Natl-Acad-Sci-U-S-A. 1985 May; 82(9): 2769-73.

Cryptic urokinase binding sites on human foreskin fibroblasts. Bajpai-A; Baker-JB. Biochem-Biophys-Res-Commun. 1985 Dec 17; 133(2): 475-82.

Intracellular modification of 125I-labeled epidermal growth factor by normal human foreskin fibroblasts. Schaudies-RP; Savage-CR Jr. Endocrinology. 1986 Feb; 118(2): 875-82.

Specific BPDE I modification of replicating and parental DNA from early S phase human foreskin fibroblasts. Ribovich-ML; Kurian-P; Milo-GE. Carcinogenesis. 1986 May; 7(5): 737-44.

The influence of 4-hydroxy-4-androstene-3,17-dione on androgen metabolism and action in cultured human foreskin fibroblasts. Hsiang-YH; Berkovitz-GD; Brown-TR; Migeon-CJ; Brodie-AM. J-Steroid-Biochem. 1987 Jan; 26(1): 131-5.

Growth control of human foreskin fibroblasts and inhibition of extracellular sialidase activity by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. Usuki-S; Hoops-P; Sweeley-CC. J-Biol-Chem. 1988 Aug 5; 263(22): 10595-9.

Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor. Story-MT. In-Vitro-Cell-Dev-Biol. 1989 May; 25(5): 402-8.

Epidermal growth factor stimulates phosphatidylinositol turnover in human foreskin fibroblasts without activation of protein kinase C. Thompson-DM; Thomas-C; Kinsey-G. J-Cell-Biochem. 1989 Dec; 41(4): 201-5.

Quantitative evaluation of the effects of human carcinogens and related chemicals on human foreskin fibroblasts. Kurian-P; Nesnow-S; Milo-GE. Cell-Biol-Toxicol. 1990 Apr; 6(2): 171-84.

Laminin on Toxoplasma gondii mediates parasite binding to the beta 1 integrin receptor alpha 6 beta 1 on human foreskin fibroblasts and Chinese hamster ovary cells. Furtado-GC; Cao-Y; Joiner-KA. Infect-Immun. 1992 Nov; 60(11): 4925-31.

Avian sarcoma virus RNA synthesis, RNA splicing and virus production in human foreskin fibroblasts: effect of co-infection with human cytomegalovirus. Knight-JB; Stinski-MF; Stoltzfus-CM. J-Gen-Virol. 1993 Dec; 74 (Pt 12): 2629-36.

Subcellular localization of annexins in human foreskin fibroblasts. Barwise-JL; Walker-JH. Biochem-Soc-Trans. 1995 Feb; 23(1): 35S.

Annexins II, IV, V and VI relocate in response to rises in intracellular calcium in human foreskin fibroblasts. Barwise-JL; Walker-JH. J-Cell-Sci. 1996 Jan; 109 ( Pt 1): 247-55.

Bradykinin induces tyrosine phosphorylation in human foreskin fibroblasts and 293 cells transfected with rat B2 kinin receptor. Tippmer-S; Bossenmaier-B; Haring-H. Eur-J-Biochem. 1996 Mar 15; 236(3): 953-9.

Haemophilus ducreyi hemolysin acts as a contact cytotoxin and damages human foreskin fibroblasts in cell culture. Alfa-MJ; DeGagne-P; Totten-PA. Infect-Immun. 1996 Jun; 64(6): 2349-52.

An isogenic haemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts. Palmer-KL; Goldman-WE; Munson-RS Jr. Mol-Microbiol. 1996 Jul; 21(1): 13-9.

Subcellular localization of annexin V in human foreskin fibroblasts: nuclear localization depends on growth state. Barwise-JL; Walker-JH. FEBS-Lett. 1996 Sep 30; 394(2): 213-6.

Attachment of Haemophilus ducreyi to human foreskin fibroblasts involves LOS and fibronectin. Alfa-MJ; DeGagne-P. Microb-Pathog. 1997 Jan; 22(1): 39-46.

Foreskins For Sale

“Parents should be wary of anyone who tries to retract their child’s foreskin, and especially wary of anyone who wants to cut it off. Human foreskins are in great demand for any number of commercial enterprises, and the marketing of purloined baby foreskins is a multimillion-dollar-a-year industry.”

Where Is My Foreskin? The Case Against Circumcision

Paul M. Fleiss, MD

Mothering (The Magazine Of Natural Family Living)

Winter 1997, page 39

Since the 1980s, private hospitals have been involved in the business of supplying discarded foreskins to private bio-research laboratories and pharmaceutical companies who require human flesh as raw research material. They also supply foreskins to transnational corporations such as Advanced Tissue Sciences of San Diego, California, [1] Organogenesis, [2] and BioSurface Technology, [3] who have recently emerged to reap new corporate profits from the sale of marketable products made from harvested human foreskins. In 1996 alone, Advanced Tissue Sciences could boast of a healthy $663.9 million market capitalization performance.[4]

A short history of the institutionalization of involuntary sexual mutilation in the United States. Hodges F. in: Denniston GC, Milos MF (eds). Sexual Mutilations: A Human Tragedy. New York: Plenum Press. 1997:17-40.

[1]. Forget pork bellies, now it’s foreskins. Manson B. San Diego Reader (May 4, 1995): 12, 14 passim.

[2]. New skin twin life- and look-save. Brewer S. Longevity (September 1992): 18.

[3]. Companies see $1.5b market in replacement skin products. Rosenberg R. Boston Globe (October 19, 1992): 22-23.

[4]. Biotech’s Big Discovery. Hall CT. San Francisco Chronicle. October 25, 1996: E1, E4.

The after market for human foreskin is where the real money is made. Foreskins are sold to biomedical companies, which use them in the manufacture of insulin. They’re also sold to middlemen, who package them for sale to research companies that in turn use them for biochemical analysis. Corporations such as Advanced Tissue Sciences (ATS), Organogenesis, BioSurface Technology, Genzyme, and Ortec International are taking cells from amputated foreskins and experimenting with artificial skin. Products like Dermagraft-TC, which sells for about $3,000 per square foot, are grown from the cells in infant foreskins and used as a temporary wound covering for burn patients. One foreskin contains enough genetic material to grow 250,000 square feet of skin.

Circumcision. Daecher M. Icon 1998;2(2):70-3.

ICCPR’s [International Covenant on Civil and Political Rights, UN GA Resolution 2200 A (XXI)] slavery, forced labor, and traffic in persons includes the industry of a growing number of American medical hospitals and medical professionals colluding with scientific agencies harvesting neonatal foreskins for skin grafts, i.e., as compulsory organ donation.

Associations like Organogenesis (Canton, MA) have received approval from the USA’s Food and Drug Administration (FDA) for its foreskin-based GraftskinTM, and has served Western Pennsylvania Hospital, with additional studies conducted at Yale University and Boston University (Stephen Brewer, New Skin Twin Life- and Look-Saver. Longevity September 1992: 18).

Another profit-oriented tissue engineering company, Advanced Tissue Sciences (La Jolla, CA), retrieves foreskins from hospitals so one foreskin can create 250,000 square feet of dermis … [T]he annual market for dermis could be $1 billion to $2 billion. Advanced Tissue Sciences has sold about $1 million worth of cultured dermis to Proctor & Gamble, Helene Curtis, and other such businesses for pre-market testing. Advanced Tissue Science’s foreskin-derived merchandise held a $32 million stock offering in the beginning of 1992 (Julie Pitta. Biosynthetics. Forbes 10 May 1993: 170-171). [The 32-page Advanced Tissue Sciences, Inc. 1997 Annual Report refers to “fibroblasts” but does not contain the word “foreskin.”]

A Boston Globe frontispiece to its Business section reads: Companies See $1.5b Market in Replacement Skin Products. This article reveals another enterprise of genital mutilation-cum-scientific advance: BioSurface Technology of Cambridge, MA. All three companies face no shortage of hoarding and retailing foreskins, and are motivated by individuals like Dr. Tania Phillips, professor of dermatology at Boston University of Medicine, insisting foreskin gathering and cultivating is scientifically and technologically “very promising.” (Ronald Rosenberg. 19 October 1992: 22-23).

The International Human Rights Challenge of Genital Mutilation & the United Nations: Initiating a Global Dialogue on the Transcultural, Multireligious, & Interdisciplinary Dimensions of Appropriating Universal Human Rights Paradigms. Zavales A. Ecumenics International Press, 1994, p. 49, footnote 34.

THE WOODLANDS, Texas–(BUSINESS WIRE)–May 16, 1995– LifeCell Corporation (Nasdaq:LIFC) today announced the culturing of human neonatal foreskin keratinocytes onto AlloDerm(R), LifeCell’s universal dermal tissue graft, to form a fully differentiated, epidermal skin layer which was then successfully grafted to an animal model. The research demonstrates the potential for generating a durable, off-the-shelf cultured skin graft product which exhibits reduced complications from blistering or scarring, according to Paul Frison, president and chief executive officer … CONTACT: LifeCell Corporation, The Woodlands / Jane Lea Hicks, 713/367-5368.

The Internet. Transmitted: 95-05-16.

One educated nurse from San Antonio told me they have to save infants’ amputated foreskins because the hospital’s Department of Oral Surgery uses them for reconstructive surgery of the inner lining of the mouth!

Report on the 1995 American Academy of Pediatrics San Francisco Convention. DeSeabra R. Intact Network Newsletter 11/1/95.

Lajolla, California. A U.S. Food and Drug (FDA) Committee recommended FDA approval of Dermagraft, artificial skin made from circumcised baby foreskins to treat diabetic foot ulcers, on condition that manufacturer Advanced Tissue Sciences, Inc., do a post-marketing study. NOCIRC’s attorney was given just five minutes to speak to the Committee in defense of the babies whose foreskins are cut off a marketed without their consent.

NOCIRC Annual Report, Spring 1998

Into these tubs, the workers add skin cells harvested from the foreskins of circumcised newborns … The two companies are independently seeking approval: Organogenesis Inc. of Canton, Mass and Advanced Tissue Sciences Inc. of La Jolla, Calif … each starts with a baby’s foreskin, a consistent, readily available source. Plus young skin grows better. One piece of foreskin can produce four acres of engineered skin with a five-day shelf life.”

The Latest From The Labs: Human Skin, The FDA is about to approve commercial use of living tissue grown by two biotech outfits.  Business Week, May 1998, Science and Technology, page 118-122

WASHINGTON (Reuters) – A new product made of human skin cells won FDA approval for use in treating certain kinds of wounds Tuesday [May 26, 1998].

The product, called Apligraf, is made of human skin cells mixed with collagen from cattle. It is made by Canton, Massachusetts-based Organogenesis.

The Food and Drug Administration said it had approved the product for use in treating venous skin ulcers, which are hard to heal because of a lack of blood flow to the skin.

“This condition is estimated to affect thousands of Americans each year, and its treatment often requires multiple surgeries,” the FDA said in a statement.

“Although Apligraf will not eliminate the need for standard treatment, it use may enhance and shorten the healing process.”

Novartis Pharmaceuticals Corp. has global marketing rights to Apligraf, the company said in a statement.

In addition to venous leg ulcers, Apligraf has been studied in burns and in skin surgery. A trial is under way in diabetic ulcers and one is expected to begin in bedsores, also known as pressure sores, later this year.

Experts say tissue engineering is starting to transform the way patients with flesh wounds are being treated.

Apligraf is made with live cells from the foreskin of a newborn’s penis — used because babies are regularly circumcised and the tissue is young and available — mixed with tissue from a cow.

“Its special composition allows it to provide wound protection and to foster the growth of healthy new skin,” the FDA said.

Reuters, 29 [?] May 1998


Sign on wall near baby being circumcised

Photograph, Parenting Magazine, July/August 1989, page 58  [The words underneath are too small to read.]

Other Published Materials Documenting the

Commercial Use of Harvested Human Foreskins

Cultured skin: applications are growing. Blacker L. Harvard Magazine (1988):4, 6, passim.

Foreskins Used in Skin Ulcer Treatments. Editor. American Medical News (October 27, 1989):38.

Treatment of skin ulcers with cultured epidermal allografts. Phillips TJ, Kehinde O, Green H, Gilchrest BA. Journal of the American Academy of Dermatology 1989;21:191-9.

So that’s what they do with it. Editor. New Physician (May-June, 1989):51.

Babies’ foreskins are used to grow tissue for burn victims. McKee R. The Gazette (Montreal) (April 5, 1995):A1-A2.

Artificial graft derived from foreskins offers diabetics hope. Mihill C. Guardian (September 5, 1997).

New tissue uses reopen circumcision debate. Foreman J. Boston Globe (January 26, 1998):C01.

BDA panel urges artificial skin. Neergaard L. Los Angeles Times (January 30, 1998). […t=/var/tmp/34d1a/aaa006brd1a83d&]

Smith & Nephew pioneers “engineered skin” treatment. Yates A. Independent (February 27, 1998):23-4.

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