Does Fluoride Lead to Alzheimer’s?

…. 1. Damaged Pineal Gland

There’s no better place to start than fluoride’s effect on the pineal gland.

The pineal gland holds huge responsibility in the body but unfortunately through 3 unique characteristics, it’s quite vulnerable to exposure to fluoride.

Leading to the calcification of the pineal gland.

main reasons fluoride accumulates in pineal gland

Once the pineal gland is calcified it becomes in/underactive.

Leaving it unable to perform its role as the body’s primary endocrine organ and main function to synthesize and secrete the hormone melatonin(10).

A vital hormone that has been reported to hold multiple roles in the central nervous system, such as improving neurogenesis and synaptic plasticity, suppressing neuroinflammation, enhancing memory function, and protecting against oxidative stress.

calcification of pineal gland

This is key to our discussion, as studies have reported reduced pineal volume and calcification in Alzheimer’s patients(11,12).

Making a damaged pineal gland the first domino to fall.

2. Decreased Melatonin Production

As fluoride calcifies the pineal gland, the pineal gland begins to produce less melatonin, a factor that is directly associated with the development of neurodegenerative diseases like Alzheimer’s (13,14,15).

This is due to melatonin’s vital function in the body.

Melatonin’s main role is to aid in brain health, specifically in the form of (16,17):

  • antioxidant defense
  • immune response
  • neuroprotective effects
  • anti-amyloid effect, and
  • anti-apoptotic activity

Most importantly, melatonin’s role as a free radical scavenger in destructive oxidant activities is most important (18). It’s without this important process that the brain of an individual is left with no ammunition to fight the natural and unnatural events occurring in one’s brain.

Specifically, lack of melatonin deprives the resources needed in hippocampal neurogenesis and hypothalamic neurogenesis(19).

With that being said, it’s no wonder Alzheimer patients have lower levels of melatonin compared to normal subjects (20), which effects don’t stop there but spread to the quality of one’s sleep.

3. Sleep Disturbances

Of all of melatonin’s functions, it’s role in directly controlling circadian rhythm (the thing that helps you sleep) is most well known (21).

Since those with Alzheimer’s have lowered melatonin levels it should be no surprise that this often leads to sleep disturbances. In fact, sleep disorders occur in up to 66% of Alzheimer’s patients (22).

Missing out on sleep, in turn robs the body of sleeps beneficial aspects. Such as tissue repair, improvement of memory consolidation, neurogenesis, and the release of diverse hormones.

Without sleep, researchers have demonstrated the increase of inflammation could boost the risk of neurodegenerative disease onset (2324). This is one of many reason, why the development of Alzheimer’s is accompanied by changes in lifestyle factors, like sleep disturbance(3).

This robs the body, particularly the brain of the opportunity to recharge and recover.

4. Fluoride Increases Oxidative Stress

Oxidative stress is the imbalance between free radical formation and their removal by antioxidants. When you have more oxidative stress that the brain can handle, it leads to damage to the brain – a process that plays a key role in Alzheimer’s (25).

Oxidative stress damages all classes of organic molecules in the cells, causing excessive lipid peroxidation and protein oxidation (26,27).

It’s as simple as if your brain were able to keep up with the damage, you’d never get Alzheimer’s.

5. Reduced Antioxidant Enzymes

In recent years, it has been recognized that higher levels of fluoride exposure result in neuronal dysfunction by increasing free radicals (oxidative stress) while also reducing the activity of antioxidants enzymes (the things that fight oxidation) (28,29)

Fluoride not only gives ammunition to the bad guys but takes ammunition from the good guys.

How To Protect The Brain From Fluoride and Alzheimer’s?

Exposure to fluoride sets-up the perfect environment for Alzheimer’s.

Fluoride crystallizes the pineal gland, turning it in/underactive.

This is followed with a decrease in melatonin production, robbing the body of what it would use in the defense of the development of Alzheimer’s. With the lack of melatonin, a person’s sleep is disrupted, robbing them of valuable time to recover their brain.

Aside from the pineal gland’s destruction by fluoride, fluoride directly damages the brain.

It increases oxidative stress and reduces antioxidant enzymes.

This essentially fuels the bad guys with machine guns and gives the good guys rocks.

fluoride's domino effect on brain health illustration

Fluoride exposure leaves a person’s brain without the resources to fight off brain damage, strips the brain of time to recover, increases destructive activity and decreases protective activities of the brain.

It would be harder to imagine a better environment for the onset of brain diseases….

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