A Brooklyn woman desperately ill with the coronavirus is breathing easy this Mother’s Day thanks to a novel treatment her medical-student son helped provide.
Josephine Bruzzese, who is 48 and otherwise healthy, woke up on March 22 with a fever, body aches, dry cough and trouble breathing. She lost the ability to smell or taste. Her family rushed her to NYU Langone Hospital-Brooklyn in Sunset Park.
“She was so short of breath she couldn’t speak” said her 23-year-old son, James.
The hospital diagnosed the mom of four with pneumonia, but with no coronavirus tests available, it sent her home as a suspected COVID-19 case.
Some symptoms improved when Bruzzese, who works in banking, was given the antibiotic azithromycin and the malaria drug hydroxychloroquine — but she still couldn’t breathe.
“We were very worried because she couldn’t stand up without almost passing out from shortness of breath,” her son said. “Her respiratory symptoms were very severe.”
James, who lives with his parents and three siblings in Bath Beach, is in his second year at the CUNY School of Medicine in a special program that combines a bachelor’s and medical degrees.
He began his undergraduate studies in the seven-year program before another family member fell ill, his 16-year-old sister Julia, who was struck by a mystery ailment in 2015 that left her unable to walk. She was later diagnosed with Lyme disease and still uses a wheelchair.
The family, who has used non-traditional therapies for Julia’s care, tried some on Josephine in a desperate bid to improve her breathing. But nothing was working.
So James sprang into action, placing a call to a key ally — Dr. Richard Horowitz, a Lyme disease specialist in the Hudson Valley who had treated Julia and for whom James has interned.
“I gave him the entire run down like I would do on rounds,” he said.
Horowitz had an idea. He suggested trying glutathione, an anti-oxidant produced by the liver that has been used to reduce inflammation in those suffering from the tick-borne illness.
“When you get a viral infection with a huge amount of inflammation you don’t have enough glutathione to be able to protect your very sensitive lung tissue,” Horowitz said.
James did not hesitate to give his mom the nutritional supplement, which they had in the house for Julia. After one 2,000-milligram dose, the family witnessed a miracle.
“Within an hour my breathing got better. It was amazing. I sat up, I got up,” Josephine Bruzzese recalled. She even started to make her bed. “I went and I took a shower.”
She took the pills for five days and had no relapse, her son said.
James wrote up his mother’s case for a study he and Horowitz coauthored on treating her and another patient, a Manhattan man in his 50s. It was published online in the journal “Respiratory Medicine Case Reports.”
The second patient told The Post he felt better after getting an intravenous infusion of the glutathione.
“Within half hour it helped with the breathing symptoms in particular,” he said.
James said he’s been spreading the word about the promising treatment by posting the study on social media and emailing it to his professors, some of whom are working on the front lines.
Doctors are already using high doses of vitamin C to treat those with the bug after it showed promise in treating coronavirus patients in China.
Dr. Purvi Parikh, an infectious disease, allergy and immunology specialist at NYU Langone Hospital, said glutathione may help in calming the immune system’s overreaction to the coronavirus known as a “cytokine storm,” but that more study was needed….
It’s just anecdotal … correlation is not causality. It needs more study. A double-blind placebo controlled 30-year longitudinal study using glutathione as a placebo should work. Our crack pharm… er, medical researchers will get right on it ….
COVID-19 Research: Findings from a new study released by Chinese researchers , Dr Wenzhong Liu from Sichuan University and Dr Hualan Li from Yibin University has revealed that the Sars-CoV-2 coronavirus attacks hemoglobin in the the red blood cells through a series of cellular actions, that ultimately renders the red blood cells incapable of transporting oxygen. https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 …..
Vitamin C elevates red blood cell glutathione in healthy adults.
We examined the effect of supplemental ascorbic acid on red blood cell glutathione. Subjects consumed self-selected vitamin C-restricted diets, and, under double-blind conditions, ingested placebo daily for week 1 (baseline), 500 mg L-ascorbate/d for weeks 2-3, 2000 mg L-ascorbate/d for weeks 4-5, and placebo daily for week 6 (withdraw). Mean red blood cell glutathione rose nearly 50% (P < 0.05) after the 500-mg period compared with baseline, and the changes from baseline for individual subjects ranged from +8% to +84%. However, the increases in plasma vitamin C and red blood cell glutathione were not correlated (r = 0.22). At the 2000-mg dosage, mean red blood cell glutathione was not significantly different from the value obtained at the 500-mg dosage. After the placebo-controlled withdraw period, red blood cell glutathione did not differ from baseline. These data indicate that vitamin C supplementation (500 mg/d) maintains reduced glutathione concentrations in blood and improves the overall antioxidant protection capacity of blood.
New York hospitals treating coronavirus patients with vitamin C
Cluelessness is not corruption. It’s just correlated with it.