Focus on Vitamin D for COVID (and much more)

… I am going to take you back to 2008 to look at Virology Journal – yes, this is about as mainstream as you can possibly get in the world of virus research. The article was called ‘On the epidemiology of influenza.‘ If you want to get your mind blown, read it 1.

It set out to answer seven questions:

  1. Why is influenza both seasonal and ubiquitous and where is the virus between epidemics?
  2. Why are the epidemics so explosive?
  3. Why do epidemics end so abruptly?
  4. What explains the frequent coincidental timing of epidemics in countries of similar latitudes?
  5. Why is the serial interval obscure?
  6. Why is the secondary attack rate so low?
  7. Why did epidemics in previous ages spread so rapidly, despite the lack of modern transport?

Yes, I realise COVID is not Influenza, but past research on influenza is about as close as you can get. Cutting to the chase, of a very long article, the authors concluded the reason why flu was far more common in winter, is because people have much lower levels of Vitamin D.

Below is their graph of vitamin D levels in the UK, at different times of the year.

vitamin d reading by month

These researchers then looked at what happened to people who took vitamin D supplements all year round. One group took placebo, one group took 800 international units (IU) a day – and one group took 800 IU per day but 2000 IU a day in the final year of the trial. Below is a graph of what they found.

vitamin d influenza

To put this another way, of those 104 subjects who took 2,000 IU of vitamin D every day, only one got a cold or influenza in the entire year.

Perhaps more importantly, if you do get infected with influenza, vitamin D (especially D3) has a potent effect on protecting endothelial cells. And damage to endothelial cells appears to be a key mechanism by which COVID creates the most severe, and potentially fatal, symptoms. Here is a section from the paper ‘Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium.

Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be largely mediated by the metabolite 1,25(OH)2D3…

Our data suggests the presence of an alternative signaling modality by which D3 acts directly on endothelial cells to prevent vascular leak. The finding that D3 and its metabolites modulate endothelial stability may help explain the clinical correlations between low serum vitamin D levels and the many human diseases with well-described vascular dysfunction phenotypes. 2

In short, it seems Vitamin D stops you getting infected with viruses and, even if you do get infected, it helps to mitigate the worst effects. This could explain results from a, not yet published study, looking at the severity of COVID infections vs. the level of Vitamin D in the blood. 3

vitamin d covid

On the face of it, remarkable benefits. However, they fit with what is already known about the benefits of vitamin D on influenza.

Further supporting the role of vitamin D in COVID, it has been recognised in many countries that those with dark skin are more likely to get infected, and die, from COVID. Here from the Guardian (UK newspaper).

I am not alone in being alarmed at the preponderance of deaths from COVID-19 among those with dark skin (UK government urged to investigate coronavirus deaths of BAME doctors, 10 April). While COVID-19 is likely to magnify the effect of social deprivation, I don’t think this is the whole story.

Vitamin D is needed for many reasons, including correct functioning of the immune system. It is converted to its active form by the action of sunlight on the skin. This is impeded by having dark skin and leads to low levels of vitamin D. Supplementing with vitamin D3 at 5000iu daily corrects this deficiency, and it is now an urgent need for all people with dark skin (and most with white). There is a reasonable chance that vitamin D replacement could help reduce the risk we are seeing playing out so tragically in the BAME community. 4

So, what do we know?

  1. Dark skinned people are more likely to die from COVID
  2. Dark skinned people are more likely to have low vitamin D levels 5
  3. Vitamin D supplements protect against colds and flu – and hopefully COVID
  4. Higher levels of Vitamin D should be able to mitigate the damage caused by COVID

The increased risks of low vitamin D levels on COVID seem dramatic, and the benefits of supplementation with vitamin D could be just as dramatic. I have been going out into the sun wherever possible in the last month. I take Vitamin D3 supplements 4,000 units a day. I strongly advise everyone else to do the same. It is snake oil, and it is free (if provided by the sun).

The only problem I see is that I cannot make any money out of this at all. Oh well. Perhaps I should claim to be making a vaccine, that could earn me billions.






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