Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada

… For decades, community water fluoridation has been used to prevent tooth decay. Water fluoridation is supplied to about 66% of US residents, 38% of Canadian residents, and 3% of European residents.1 In fluoridated communities, fluoride from water and beverages made with tap water makes up 60% to 80% of daily fluoride intake in adolescents and adults.2

Fluoride crosses the placenta,3 and laboratory studies show that it accumulates in brain regions involved in learning and memory4 and alters proteins and neurotransmitters in the central nervous system.5 Higher fluoride exposure from drinking water has been associated with lower children’s intelligence in a meta-analysis6 of 27 epidemiologic studies and in studies7,8 including biomarkers of fluoride exposure. However, most prior studies were cross-sectional and conducted in regions with higher water fluoride concentrations (0.88-31.6 mg/L; to convert to millimoles per liter, multiply by 0.05263) than levels considered optimal (ie, 0.7 mg/L) in North America.9 Further, most studies did not measure exposure during fetal brain development. In a longitudinal birth cohort study involving 299 mother-child pairs in Mexico City, Mexico, a 1-mg/L increase in maternal urinary fluoride (MUF) concentration was associated with a 6-point (95% CI, −10.84 to −1.74) lower IQ score among school-aged children.10 In this same cohort, MUF was also associated with more attention-deficit/hyperactivity disorder–like symptoms.11 Urinary fluoride concentrations among pregnant women living in fluoridated communities in Canada are similar to concentrations among pregnant women living in Mexico City.12 However, it is unclear whether fluoride exposure during pregnancy is associated with cognitive deficits in a population receiving optimally fluoridated water.

This study examined whether exposure to fluoride during pregnancy was associated with IQ scores in children in a Canadian birth cohort in which 40% of the sample was supplied with fluoridated municipal water….

Exposures  Maternal urinary fluoride (MUFSG), adjusted for specific gravity and averaged across 3 trimesters available for 512 pregnant women, as well as self-reported maternal daily fluoride intake from water and beverage consumption available for 400 pregnant women.

Main Outcomes and Measures  Children’s IQ was assessed at ages 3 to 4 years using the Wechsler Primary and Preschool Scale of Intelligence-III. Multiple linear regression analyses were used to examine covariate-adjusted associations between each fluoride exposure measure and IQ score.

Results  Of 512 mother-child pairs, the mean (SD) age for enrollment for mothers was 32.3 (5.1) years, 463 (90%) were white, and 264 children (52%) were female. Data on MUFSG concentrations, IQ scores, and complete covariates were available for 512 mother-child pairs; data on maternal fluoride intake and children’s IQ were available for 400 of 601 mother-child pairs. Women living in areas with fluoridated tap water (n = 141) compared with nonfluoridated water (n = 228) had significantly higher mean (SD) MUFSG concentrations (0.69 [0.42] mg/L vs 0.40 [0.27] mg/L; P = .001; to convert to millimoles per liter, multiply by 0.05263) and fluoride intake levels (0.93 [0.43] vs 0.30 [0.26] mg of fluoride per day; P = .001). Children had mean (SD) Full Scale IQ scores of 107.16 (13.26), range 52-143, with girls showing significantly higher mean (SD) scores than boys: 109.56 (11.96) vs 104.61 (14.09); P = .001. There was a significant interaction (P = .02) between child sex and MUFSG (6.89; 95% CI, 0.96-12.82) indicating a differential association between boys and girls. A 1-mg/L increase in MUFSG was associated with a 4.49-point lower IQ score (95% CI, −8.38 to −0.60) in boys, but there was no statistically significant association with IQ scores in girls (B = 2.40; 95% CI, −2.53 to 7.33). A 1-mg higher daily intake of fluoride among pregnant women was associated with a 3.66 lower IQ score (95% CI, −7.16 to −0.14) in boys and girls.

Conclusions and Relevance  In this study, maternal exposure to higher levels of fluoride during pregnancy was associated with lower IQ scores in children aged 3 to 4 years. These findings indicate the possible need to reduce fluoride intake during pregnancy….

https://jamanetwork.com/journals/jamapediatrics/fullarticle/2748634

Prediction: nothing will change, ever, even though the original rationale for drinking fluoridated water has collapsed (it only works topically) and in practice there is no difference in tooth decay rates in fluoridated vs non-fluoridated communities.

But try agitating for a change in fluoridation policy in your local city council.   You will be seen as a “conspiracy theorist”.  They are well trained to ignore rationality and science and delegate their responsibilities to “authorities” in the “public health” establishment in washington.   The notion that the washington regime might have an agenda other than the health of the population is inconceivable to them.   Maybe because they’re drinking fluoridated water.

Water Fluoridation Increases Suggestibility

Fluoride & IQ: The 53 Studies

As of June 2018, a total of 60 studies have investigated the relationship between fluoride and human intelligence, and over 40 studies have investigated the relationship fluoride and learning/memory in animals. Of these investigations, 53 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while 45 animal studies have found that fluoride exposure impairs the learning and/or memory capacity of animals. The human studies, which are based on IQ examinations of over 15,000 children, provide compelling evidence that fluoride exposure during the early years of life can damage a child’s developing brain.

After reviewing 27 of the human IQ studies, a team of Harvard scientists concluded that fluoride’s effect on the young brain should now be a “high research priority.” (Choi, et al 2012). Other reviewers have reached similar conclusions, including the prestigious National Research Council (NRC), and scientists in the Neurotoxicology Division of the Environmental Protection Agency (Mundy, et al). In the table below, we summarize the results from the 51 studies that have found associations between fluoride and reduced IQ and provide links to full-text copies of the studies. For a discussion of the 7 studies that did not find an association between fluoride and IQ, click here….

Fluoride & IQ: The 53 Studies

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