Clues to brain differences between males and females

Predictably and monotonously, the research community is obsessed with investigating every possible contributor to gender-dependent social behavior, except the most obvious one, the one they studiously ignore, which is of course imprinted sexual violence and genital mutilation.

That said, this is interesting research.   The amygdala is involved in processing emotions such as fear https://en.wikipedia.org/wiki/Amygdala_hijack while the endocannabinoid system is involved in  stress and pain perception.   No relevance to the above I’m sure.

Researchers at the University of Maryland School of Medicine have discovered a mechanism for how androgens — male sex steroids — sculpt brain development. The research, conducted by Margaret M. McCarthy, Ph.D., who Chairs the Department of Pharmacology, could ultimately help researchers understand behavioral development differences between males and females….

A key contributor to the differences in play behavior between males and females is a sex-based difference in the number of newborn cells in the part of the brain called the amygdala, which controls emotions and social behaviors. The research showed that males have fewer of these newborn cells, because they are actively eliminated by immune cells.

In females, the newborn cells differentiated into a type of glial cell, the most abundant type of cell in the central nervous system. In males however, testosterone increased signaling at receptors in the brain which bind endocannabinoids, causing immune cells to be activated. The endocannabinoids prompted the immune cells to effectively eliminate the newborn cells in males. Females rats in the study were unaffected, suggesting that the activation of the immune cells by the increased endocannabinoids in males was necessary for cell elimination. In this respect, this research shows that cannabis use, which stimulates endocannabinoids in the brain and nervous system, could impact brain development of the fetus and this impact could differ between male and female fetuses….

https://www.sciencedaily.com/releases/2019/03/190301160901.htm

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