Front. Public Health | doi: 10.3389/fpubh.2016.00270
Vaccination and Health Outcomes: A Survey of 6- to 12-year-old Vaccinated and Unvaccinated Children based on Mothers’ Reports
- 1Epidemiology and Biostatistics, School of Public Health (Initiative), Jackson State University, USA
- 2National Home Education Research Institute, USA
- 3Epidemiology and Biostatistics, School of Public Health (Initiative), USA
- 4Former Graduate Student, Jackson State University, School of Public Health (Initiative), USA
Background: Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among US children. Yet the long-term health outcomes of the routine vaccination program remain unknown. Studies have been recommended by the Institute of Medicine to address this question.
Specific Aims: To compare vaccinated and unvaccinated children on a broad range of health outcomes, and to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if any, remains significant after adjustment for other measured factors.
Design: A cross-sectional survey of mothers of children educated at home.
Methods: Homeschool organizations in four states (Florida, Louisiana, Mississippi, and Oregon) were asked to forward an email to their members, requesting mothers to complete an anonymous online questionnaire on the vaccination status and health outcomes of their biological children ages 6 to 12.
Results: A total of 415 mothers provided data on 666 children, of which 261 (39%) were unvaccinated. Vaccinated children were significantly less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but significantly more likely to have been diagnosed with pneumonia, otitis media, allergies and NDDs (defined as Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, and/or a learning disability). After adjustment, the factors that remained significantly associated with NDD were vaccination (OR 3.1, 95% CI: 1.4, 6.8), male gender (OR 2.3, 95% CI: 1.2, 4.3), and preterm birth (OR 5.0, 95% CI: 2.3, 11.6). In a final adjusted model, vaccination but not preterm birth remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5).
Conclusions: In this study based on mothers’ reports, the vaccinated had a higher rate of allergies and NDD than the unvaccinated. Vaccination, but not preterm birth, remained significantly associated with NDD after controlling for other factors. However, preterm birth combined with vaccination was associated with an apparent synergistic increase in the odds of NDD. Further research involving larger, independent samples is needed to verify and understand these unexpected findings in order to optimize the impact of vaccines on children’s health.
Keywords: Acute diseases; Chronic diseases; Epidemiology; Evaluation; Health policy; Immunization; Neurodevelopmental disorders; Vaccination, Acute diseases, chronic diseases, Epidemiology, Evaluation, Health Policy, Immunization, Neurodevelopmental disorders, Vaccination
Citation: Mawson AR, Ray BD, Bhuiyan AR and Jacob B (2016). Vaccination and Health Outcomes: A Survey of 6- to 12-year-old Vaccinated and Unvaccinated Children based on Mothers’ Reports.Front. Public Health4:270. doi: 10.3389/fpubh.2016.00270
Received: 17 Sep 2016; Accepted: 21 Nov 2016.
Amit Agrawal, Gandhi Medical College, India
Copyright: © 2016 Mawson, Ray, Bhuiyan and Jacob. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Anthony R. Mawson, School of Public Health (Initiative), Jackson State University, Epidemiology and Biostatistics, 350 West Woodrow Wilson Avenue, Jackson, 39213, Mississippi, USA, email@example.com
The original link for this article:
was taken down within hours of publication but this was found on google cache here:
But now I see the cache is gone too. The medical thought police are drinking too much coffee today. Luckily: