Microwave and other low frequency electromagnetic fields (EMFs) have been shown to act by activating voltage-gated calcium channels (VGCCs) with most biological effects being due to elevated intracellular calcium, consequent nitric oxide (NO) elevation and either peroxynitrite or NO signaling. This, the role of excessive intracellular calcium in microwave effects and some 20,000 papers on microwave biological effects show that the current international safety standards do not predict biological hazard. Such standards are based on the false assumption that the predominant effects of microwave and other low frequency EMF exposures are due to heating. A whole series of biological changes reportedly produced by microwave exposures can now be explained in terms of this new paradigm of EMF action via VGCC activation, including: oxidative stress; single and double stranded breaks in cellular DNA; therapeutic effects; blood-brain barrier breakdown; greatly depressed melatonin levels and sleep disruption; cancer; male and female infertility; immune dysfunction; neurological dysfunction; cardiac dysfunction including tachycardia, arrhythmia and sudden cardiac death. A two-phase program for greatly improving EMF safety standards is proposed.